Nbr 6461 Bloco Ceramico Para Alvenaria Verificacao Da Resistencia A Compressao.pdf
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Category:Stainless steelBiotransformation of propofol by rat hepatic microsomes.
The biotransformation of propofol was studied using freshly isolated and incubated rat hepatic microsomes. Propofol was converted to a metabolite(s) identified as 4-hydroxypropofol by gas chromatography/mass spectrometry (GC/MS) and high performance liquid chromatography (HPLC). Formation of 4-hydroxypropofol is greatest with freshly isolated microsomes and is inhibited by a low concentration of sodium taurocholate, but not by potassium cyanide. The Michaelis constant (Km) is approximately 6 X 10(-5) M and the maximum velocity (Vmax) is approximately 1.8 X 10(-4) M/min. Propofol is also biotransformed to hydroxypentofol and to a lesser extent to 2- and 4-hydroxypentofol by incubated microsomes. There is no difference in the Vmax for the formation of these two metabolites with either freshly isolated or incubated microsomes. The Km for the production of hydroxypentofol is greater than 1.5 X 10(-5) M. The formation of the two metabolites is inhibited by cyanide. The kinetic study shows that propofol undergoes two metabolic pathways in hepatic microsomes. In addition to the formation of 4-hydroxypropofol, propofol can be biotransformed to hydroxypentofol. The hepatic microsomal metabolism of propofol occurs via cytochrome P-450.The Gopher Douchey, he likes to say, has been a staple of the web for some 15 years.
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